Resources: Bibliography

Learn how other researchers have used our CMS data to publish papers in high-impact journals.

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Genome-Wide Analysis of Sex Disparities in the Genetic Architecture of Lung and Colorectal Cancers

Almost all complex disorders have manifested epidemiological and clinical sex disparities which might partially arise from sex-specific genetic mechanisms. Addressing such differences can be important from a precision medicine perspective which aims to make medical interventions more personalized and effective.

Nazarian, A., Kulminski, A.M.

Genes

2021

Functional Trajectories at the End of Life for Individuals with Dementia: Issue Brief

For this project, we used a sample of decedents from the 2000-2012 Health and Retirement Study to understand the trajectories of functional decline of older adults with dementia near the EOL, and how these trajectories differ from those of people without dementia. In addition, we examined whether and how these trajectories vary by other patient characteristics such as demographics, comorbidities, and access to caregiving.

Broyles, I., Huebeler, A., Dave, I., Graf, E., Li, Q., Palmer, L., Feng, Z., and Karon, S.

Office of the Assistant Secretary for Planning and Evaluation (ASPE), Department of Health and Human Services (HHS)

2020

Functional Trajectories at the End Of Life For Individuals With Dementia: Final Report

For this project, we used a sample of decedents from the 2000-2012 Health and Retirement Study to understand the trajectories of functional decline of older adults with dementia near the EOL, and how these trajectories differ from those of people without dementia. In addition, we examined whether and how these trajectories vary by other patient characteristics such as demographics, comorbidities, and access to caregiving.

Broyles, I., Huebeler, A., Dave, I., Graf, E., Li, Q., Palmer, L., Feng, Z., and Karon, S.

Office of the Assistant Secretary for Planning and Evaluation (ASPE), Department of Health and Human Services (HHS)

2020

Accuracy of Diagnosis and Health Service Codes in Identifying frailty in Medicare Data

Background: Capturing frailty within administrative claims data may help to identify high-risk patients and inform population health management strategies. Although it is common to ascertain frailty status utilizing claims-based surrogates (e.g. diagnosis and health service codes) selected according to clinical knowledge, the accuracy of this approach has not yet been examined. We evaluated the accuracy of claims-based surrogates against two clinical definitions of frailty.

Festa, N., Shi, S., and Kim, D.

BMC Geriatrics

2020

Measuring Frailty in Administrative Claims Data: Comparative Performance of Four Claims-Based Frailty Measures in the U.S. Medicare Data

Background: There has been increasing effort to measure frailty in the U.S. Medicare data. The performance of claims-based frailty measures has not been compared.

Kim, D., Patorno, E., Pawar, A., Lee, H., Schneeweiss, S., and Glynn, R.

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

2020

Quantitative and Qualitative Role of Antagonistic Heterogeneity in Genetics of Blood Lipids

Prevailing strategies in genome-wide association studies (GWAS) mostly rely on principles of medical genetics emphasizing one gene, one function, one phenotype concept. Here, we performed GWAS of blood lipids leveraging a new systemic concept emphasizing complexity of genetic predisposition to such phenotypes.

Kulminski, A.M., Loika, Y., Nazarian, A., Culminskaya, I.

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

2020

Haplotype Architecture of the Alzheimer's Risk in the APOE rRegion via Co-Skewness

As a multifactorial polygenic disorder, Alzheimer's disease (AD) can be associated with complex haplotypes or compound genotypes.

Kulminski, A.M., Philipp, I., Loika, Y., He, L., Culminskaya, I.

Alzheimer's & Dementia

2020

Genetic and Regulatory Architecture of Alzheimer's Disease in the APOE Region

Apolipoprotein E (APOE) e2 and e4 alleles encoded by rs7412 and rs429358 polymorphisms, respectively, are landmark contra and pro "risk" factors for Alzheimer's disease (AD).

Kulminski, A.M., Shu, L., Loika, Y., Nazarian, A., Arbeev, K.G., Ukraintseva, S., Yashin, A. I., Culminskaya, I.

Alzheimer's & Dementia

2020

Summary-Based Methylome-Wide Association Analyses Suggest Potential Genetically Driven Epigenetic Heterogeneity of Alzheimer's Disease

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with no curative treatment available. Exploring the genetic and non-genetic contributors to AD pathogenesis is essential to better understand its underlying biological mechanisms, and to develop novel preventive and therapeutic strategies.

Nazarian, A., Yashin, A. I., Kulminski, A.M.

Journal of Clinical Medicine

2020

Implications of the Use of Algorithmic Diagnoses or Medicare Claims to Ascertain Dementia

Formal dementia ascertainment with research criteria is resource-intensive, prompting the growing use of alternative approaches. Our objective was to illustrate the potential bias and implications for study conclusions introduced through the use of alternate dementia ascertainment approaches.

Power, M.C., Gianattasio, K.Z., Ciarleglio, A.

Neuroepidemiology

2020

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