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Almost all complex disorders have manifested epidemiological and clinical sex disparities which might partially arise from sex-specific genetic mechanisms. Addressing such differences can be important from a precision medicine perspective which aims to make medical interventions more personalized and effective.
Nazarian, A., Kulminski, A.M.
Genes
2021
For this project, we used a sample of decedents from the 2000-2012 Health and Retirement Study to understand the trajectories of functional decline of older adults with dementia near the EOL, and how these trajectories differ from those of people without dementia. In addition, we examined whether and how these trajectories vary by other patient characteristics such as demographics, comorbidities, and access to caregiving.
Broyles, I., Huebeler, A., Dave, I., Graf, E., Li, Q., Palmer, L., Feng, Z., and Karon, S.
Office of the Assistant Secretary for Planning and Evaluation (ASPE), Department of Health and Human Services (HHS)
2020
For this project, we used a sample of decedents from the 2000-2012 Health and Retirement Study to understand the trajectories of functional decline of older adults with dementia near the EOL, and how these trajectories differ from those of people without dementia. In addition, we examined whether and how these trajectories vary by other patient characteristics such as demographics, comorbidities, and access to caregiving.
Broyles, I., Huebeler, A., Dave, I., Graf, E., Li, Q., Palmer, L., Feng, Z., and Karon, S.
Office of the Assistant Secretary for Planning and Evaluation (ASPE), Department of Health and Human Services (HHS)
2020
Background: Capturing frailty within administrative claims data may help to identify high-risk patients and inform population health management strategies. Although it is common to ascertain frailty status utilizing claims-based surrogates (e.g. diagnosis and health service codes) selected according to clinical knowledge, the accuracy of this approach has not yet been examined. We evaluated the accuracy of claims-based surrogates against two clinical definitions of frailty.
Festa, N., Shi, S., and Kim, D.
BMC Geriatrics
2020
Background: There has been increasing effort to measure frailty in the U.S. Medicare data. The performance of claims-based frailty measures has not been compared.
Kim, D., Patorno, E., Pawar, A., Lee, H., Schneeweiss, S., and Glynn, R.
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
2020
Prevailing strategies in genome-wide association studies (GWAS) mostly rely on principles of medical genetics emphasizing one gene, one function, one phenotype concept. Here, we performed GWAS of blood lipids leveraging a new systemic concept emphasizing complexity of genetic predisposition to such phenotypes.
Kulminski, A.M., Loika, Y., Nazarian, A., Culminskaya, I.
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
2020
As a multifactorial polygenic disorder, Alzheimer's disease (AD) can be associated with complex haplotypes or compound genotypes.
Kulminski, A.M., Philipp, I., Loika, Y., He, L., Culminskaya, I.
Alzheimer's & Dementia
2020
Apolipoprotein E (APOE) e2 and e4 alleles encoded by rs7412 and rs429358 polymorphisms, respectively, are landmark contra and pro "risk" factors for Alzheimer's disease (AD).
Kulminski, A.M., Shu, L., Loika, Y., Nazarian, A., Arbeev, K.G., Ukraintseva, S., Yashin, A. I., Culminskaya, I.
Alzheimer's & Dementia
2020
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with no curative treatment available. Exploring the genetic and non-genetic contributors to AD pathogenesis is essential to better understand its underlying biological mechanisms, and to develop novel preventive and therapeutic strategies.
Nazarian, A., Yashin, A. I., Kulminski, A.M.
Journal of Clinical Medicine
2020
Formal dementia ascertainment with research criteria is resource-intensive, prompting the growing use of alternative approaches. Our objective was to illustrate the potential bias and implications for study conclusions introduced through the use of alternate dementia ascertainment approaches.
Power, M.C., Gianattasio, K.Z., Ciarleglio, A.
Neuroepidemiology
2020
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